
PUBLICATIONS
2023
Canals I, Comella-Bolla A, Cepeda-Prado E, Avaliani N, Crowe JA, Oburoglu L, Bruzelius A, King N, Pajares MA, Pérez-Sala D, Heuer A, Rylander Ottosson D, Soriano J, Ahlenius H. Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia. Brain Communications. 2023. doi: 10.1093/braincomms/fcad158.
Giacomoni J, Habekost M, Cepeda-Prado E, Mattsson B, Ottosson DR, Parmar M, Kajtez J. Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices. STAR Protoc. 2023 Jan 18;4(1):102041. doi: 10.1016/j.xpro.2022.102041.
2022
Sozzi E, Kajtez J, Bruzelius A, Wesseler MF, Nilsson F, Birtele M, Larsen NB, Ottosson DR, Storm P, Parmar M, Fiorenzano A. Silk scaffolding drives self-assembly of functional and mature human brain organoids. Front Cell Dev Biol. 2022 Oct 14;10:1023279. doi: 10.3389/fcell.2022.1023279.
Birtele M, Storm P, Sharma Y, Kajtez J, Wahlestedt JN, Sozzi E, Nilsson F, Stott S, He XL, Mattsson B, Ottosson DR, Barker RA, Fiorenzano A, Parmar M. Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain. Development. 2022 Oct 28:dev.200504. doi: 10.1242/dev.200504.
Drouin-Ouellet J, Legault EM, Nilsson F, Pircs K, Bouquety J, Petit F, Shrigley S, Birtele M, Pereira M, Storm P, Sharma Y, Bruzelius A, Vuono R, Kele M, Stoker TB, Ottosson DR, Falk A, Jakobsson J, Barker RA, Parmar M. Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease. Stem Cell Reports. 2022 Oct 11;17(10):2203-2219. doi: 10.1016/j.stemcr.2022.08.010.
Kajtez J, Wesseler MF, Birtele M, Khorasgani FR, Rylander Ottosson D, Heiskanen A, Kamperman T, Leijten J, Martínez-Serrano A, Larsen NB, Angelini TE, Parmar M, Lind JU, Emnéus J. Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs. Adv Sci (Weinh). 2022 Sep;9(25):e2201392. doi: 10.1002/advs.202201392.
2021
Fiorenzano A, Sozzi E, Birtele M, Kajtez J, Giacomoni J, Nilsson F, Bruzelius A, Sharma Y, Zhang Y, Mattsson B, Emnéus J, Ottosson DR, Storm P, Parmar M. Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. Nat Commun. 2021 Dec 15;12(1):7302. doi: 10.1038/s41467-021-27464-5.
Bruzelius A, Kidnapillai S, Drouin-Ouellet J, Stoker T, Barker RA, Rylander Ottosson D. Reprogramming Human Adult Fibroblasts into GABAergic Interneurons. Cells. 2021; 10(12):3450. https://doi.org/10.3390/cells10123450
Kidnapillai S, Ottosson DR. Functional Assessment of Direct Reprogrammed Neurons In Vitro and In Vivo. Methods Mol Biol. 2021;2352:183-199. doi: 10.1007/978-1-0716-1601-7_13.
Rylander Ottosson D, Grade S and Heuer A. Editorial: Regeneration and Brain Repair. Front. Cell. Neurosci.2021;15:687992.
doi: 10.3389/fncel.2021.687992
2020